On the status of autoimmunity in the disorders of schizophrenic and depressive spectra*

Аннотация

The immunopathological process is known to be a typical facet for many disorders of the nervous system. In this study, quantitative and functional parameters were used to assess the immune system status in patients with schizophrenia, affective disorders, organic brain diseases with psychotic disorders, and multiple sclerosis. The results confirm the possible role of autoimmune reactions in the structure of the pathogenesis of endogenous mental disorders. The immunological profiles in schizophrenia and affective disorders were very similar. Patients with later onset of schizophrenia have shown higher levels of C-reactive protein. It may
indicate its important role in the development of schizophrenia in this particular group of patients. Also, patients with schizophrenia having higher levels of neuron-specific enolase and C-reactive protein suffered from more severe thinking impairment.

Ключевые слова:

autoimmunity, schizophrenic disorders spectrum, depressive disorders spectrum, neuron-specific antigens, galactocerebrosides, S-100 protein, neuron-specific enolase, glial fibrillary acidic protein