The The analysis of the secondary structure of the proteins in blood serum of patients with multiple myeloma*

Авторы

  • Елена Чихиржина Институт цитологии Российской академии наук
  • Андрей Гарифуллин Russian Scientific Research Institute of Hematology and Transfusiology, 16, 2-ya Sovetskaya ul., St. Petersburg, 191024, Russian Federation https://orcid.org/0000-0003-0946-383X
  • Алексей Кувшинов Russian Scientific Research Institute of Hematology and Transfusiology, 16, 2-ya Sovetskaya ul., St. Petersburg, 191024, Russian Federation
  • Людмила Плотникова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0002-3143-7630
  • Александр Поляничко Institute of Cytology of the Russian Academy of Sciences, 4, Tikhoretsky pr., St. Petersburg, 194064, Russian Federation;St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Елизавета Тельная St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Pavlov First St. Petersburg State Medical University, 6–8, L’va Tolstogo ul., St. Petersburg, 197022, Russian Federation
  • Сергей Волошин Russian Scientific Research Institute of Hematology and Transfusiology, 16, 2-ya Sovetskaya ul., St. Petersburg, 191024, Russian Federation ; North-Western State Medical University named after I.I.Mechnikov, 41, Kirochnaya ul., St. Petersburg, 191015, Russian Federation ;S.M.Kirov Military Medical Academy, 6, ul. Akademika Lebedeva, St. Petersburg, 194044, Russian Federation https://orcid.org/0000-0003-1784-0375

DOI:

https://doi.org/10.21638/spbu11.2019.435

Аннотация

Multiple myeloma (MM) is one of the most common hematologic diseases in the world, which is characterized by the proliferation of clonal plasma cells in the bone marrow producing a monoclonal immunoglobulin. In this research, analysis of the secondary structure of proteins in blood serum of patients with MM and healthy donors was carried out by an infrared spectroscopy method. There were shown a decrease in the average content of α-helical sites and an increase in the number of β-layered structures in blood serum proteins of patients with MM compared to healthy donors.

Ключевые слова:

multiple myeloma, infrared spectroscopy, secondary structure of proteins

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Загрузки

Опубликован

15.06.2020

Как цитировать

Чихиржина, Е., Гарифуллин , А., Кувшинов, А., Плотникова, Л., Поляничко, А., Тельная, Е., & Волошин, С. (2020). The The analysis of the secondary structure of the proteins in blood serum of patients with multiple myeloma*. Вестник Санкт-Петербургского университета. Медицина, 14(4), 394–398. https://doi.org/10.21638/spbu11.2019.435

Выпуск

Раздел

Онкология