Effect of collagen breakdown products on mast cell activity during reparative regeneration

Авторы

  • Баира Санданова Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation https://orcid.org/0000-0002-6093-0088
  • Цындыма Баясхаланова Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation
  • Кондратьева Евгения Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation
  • Обыденко Валентина Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation
  • Баранчугова Лариса Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.424

Аннотация

Immune system including its effector cells and their products (autocoids and autoantibodies) definetly plays an important part in regulation of tissue regeneration. Collagen-based preparations, whose action is due to peptides that have a stimulating effect on the formation of self collagen and bone restoration, as well as indirectly affecting hemostasis and phagocytosis, have gained considerable interest because of frequent bacterial complications of wound healing. The effect of mast cells on the healing process of the wound surface in rats under the influence of collagen dissolution products was assessed in the present study. According to the results, mast cells were found to be activated on the wound surface under the influence of drugs based on collagen breakdown products, which directly caused an acceleration of the reparative regeneration process.

Ключевые слова:

regeneration, mast cells, morphology, skin wound, collagen

Скачивания

Данные скачивания пока недоступны.
 

Биография автора

Обыденко Валентина , Chita State Medical Academy, 39a, ul. Gor’kogo, Chita, 672000, Russian Federation

 

 

Библиографические ссылки


References

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Alekseeva N.T., Klochkova S.V., Nikityuk D.B. Morphological characteristics of mast cells during skin regeneration. Orenburgskii meditsinskii vestnik, 2016, no. 3, pp. 13–16. (In Russian)

Alekseeva N.T., Nikityuk D.B., Klochkova S.V. Analytical morphology of reparative regeneration in the skin under the influence of various regional factors. Zhurnal anatomii i gistopatologii, 2015, vol. 4,no. 1, pp. 26–37. (In Russian)

Baranchugova L.M., Obydenko V.I., Rusaeva N. S. Morphological features of wound regeneration under the influence of collagen dissolution products. Mezhdunarodnyi nauchno-issledovatel’skiy zhurnal,2014, no. 6, pp. 61–63. (In Russian)

Bobr O.A., Myadelets O.D., Dubovsky V.V. Dynamics of mast cell population during the wound process in rats subjected to hypobiotic conditions (starvation, hypothermia). Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta, 2006, no. 4, pp. 1–9. (In Russian)

Komi D.E.A., Ribatti D. Mast cell mediated mechanistic pathways in organ transplantation. Europ. J.Pharmacol., 2019, p. 172458.

Загрузки

Опубликован

15.06.2020

Как цитировать

Санданова, Б., Баясхаланова, Ц., Кондратьева, Е., Обыденко, В., & Баранчугова, Л. (2020). Effect of collagen breakdown products on mast cell activity during reparative regeneration. Вестник Санкт-Петербургского университета. Медицина, 14(4), 350–352. https://doi.org/10.21638/spbu11.2019.424

Выпуск

Том 14 № 4 (2019)

Раздел

Внутренние болезни

Лицензия

Статьи журнала «Вестник Санкт-Петербургского университета. Медицина» находятся в открытом доступе и распространяются в соответствии с условиями Лицензионного Договора с Санкт-Петербургским государственным университетом, который бесплатно предоставляет авторам неограниченное распространение и самостоятельное архивирование.