The human placenta and aneuploidy — trisomies 21, 18, 13

Авторы

  • Андрей Колобов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Анна Лычёва St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Вадим Карев Pediatric Research and Clinical Center for Infectious Diseases, 9, ul. Prof. Popova, St. Petersburg, 197022, Russian Federation
  • Оксана Колобова St. Petersburg State Pediatric Medical University, 2, Litovskaya ul., St. Petersburg, 194100, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2020.103

Аннотация

The purpose of this research was to investigation the morphological features of human placenta with karyotyped trisomy 21, 18 and 13 chromosomes. The study included 50 placenta of fetuses in miscarriages pregnancy at 19–20 weeks, among them 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 21 of the fetuses; 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 18 of the fetuses; 10 placentas obtained as a result of induced abortions due to karyotyped trisomy 13 in the fetuses; 20 placentas obtained as a result of spontaneous miscarriages without any congenital defects and abnormal karyotype of the fetuses. As a result of the investigation, in placentas with karyotyped trisomies, a violation of villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic
changes in villus stroma and inhibition of angiogenesis were noted. As a result of the study, in placentas with karyotyped trisomies, a violation of villi branching was noted. With karyotyped trisomy 21, inhibition of angiogenesis and sclerosis of villi with proliferation of fibroblasts were revealed. In cells of chorionic villi with karyotyped trisomy 18, increased apoptosis was noted. In placentas with karyotyped trisomy 13 hydropic changes in villus stroma and inhibition of angiogenesis were noted.

Ключевые слова:

trisomy, placenta, immunohistochemical analysis, angiogenesis, apoptosis

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Опубликован

18.11.2020

Как цитировать

Колобов, А., Лычёва, А., Карев , В., & Колобова, О. (2020). The human placenta and aneuploidy — trisomies 21, 18, 13. Вестник Санкт-Петербургского университета. Медицина, 15(1), 24–31. https://doi.org/10.21638/spbu11.2020.103

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Раздел

Внутренние болезни