Ageing Acceleration and Disease Onset: Ontogenetic Specificity of Pathogenetic Mechanisms

  • Sorin Riga “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 10–12, Berceni av., Sector 4, 041914, Bucharest, Romania
  • Magdalena Budisteanu “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 10–12, Berceni av., Sector 4, 041914, Bucharest, Romania
  • Bogdan Budisteanu “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 10–12, Berceni av., Sector 4, 041914, Bucharest, Romania
  • Vlad Dionisie “Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 10–12, Berceni av., Sector 4, 041914, Bucharest, Romania“Prof. Dr. Alexandru Obregia” Clinical Hospital of Psychiatry, 10–12, Berceni av., Sector 4, 041914, Bucharest, Romania
  • Vitalie V. Scripnic International Free University of Moldova, 52, Vlaicu Pârcălab str., MD–2012, Chisinau, Republic of Moldova

Аннотация

The article which unfortunately happened to be the last poshumous paper published by recently deseased Prof. Habil. Dan Riga, MD, PhD, DHc, is devoted to the problem of imperfection and vulnerability of the natural genetically determined adaptation mechanisms available to human being. All defensive mechanisms encoded in human reactivity are principally imperfect and have to cause secondary harm. It means that the very defence is pathogenic, especially in chronic situations when the natural cost of adaptation increases to unbearably high level. That is central paradigm of the whole science of Pathophysiology. The imperfection and secondary pathogenicity of natural defence (autopathokinesis) was emphasized earlier, since first coined by August Weismann, for example in works published by L. P. Churilov. This article analyses the basic aspects of health and disease under the aforementioned bias, with original interpretation of the role of vulnerability and imperfection of human defensive mechanisms in chronic repeated stress and within the continuum of physiologic and pathological senescence. The principle is illustrated by several examples from the general pathology of typical pathological processes and with the correlations to most important geriatric syndromes and diseases. According the statements of the authors, the human being has an ontogenetic route, from childhood and youth health, through adulthood, towards old age (senescence) and related multiple pathology (including dementia). Human vulnerability is extremely complex and manifests at different levels: macromolecular, sub-cellular, cellular, tissual, of organs, of biological system, with additional specific traits for the central nervous system. Slowly, throughout individual ontogenesis, closely related to vulnerability, an etiopathogenic cascade (tetrad) develops: it is entropic, of structures disorganisation and disturbance of their functioning: distress wear-and-tear “ageing” poly-pathology. Its dynamics is self-sustained, aggravated, and
rendered more complex by vicious patho-physiological multiplication circuits.

Скачивания

Данные скачивания пока недоступны.

Литература


References

Ativie F. The role of endocannabinoid system in neuron-glial communicationin in the ageing and diseased brain. PhD Thesis at Rheinischen Friedrich-Wilhelms-Universität Bonn. Bonn, 2017.

Auer R. N., Benveniste H. Hypoxia and related conditions, In: D. I. Graham, P. L. Lantos (Eds). Greenfield’s Neuropathology, 6th ed. London, Arnold, 1997, pp. 263–314.

Benveniste H., Drejer J., Schousboe A., Diemer N. H. Elevation of the extracellular concentrations of glutamate and aspartate în rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem., 1984, vol. 43, pp. 1369–1374.

Bikov Y. V., Bekker R. A., Reznikov M. K. Depression and Resistance. Practical Guide. Moscow, Infra-M, 2013. (In Russian)

Burns A., Lawlor B., Craig S. (Eds.). Assessment Scales in Old Age Psychiatry. London, Martin Dunitz,1999.

Carr J. A. Shortwave infrared imaging and its translation to clinically-relevant designs. PhD Thesis at Massachusetts Institute of Technology, Cambridge, MA, 2018.

Chrousos G. P., McCarty R., Pacak K. et al. (Eds.). Stress-Basic Mechanisms and Clinical Implications. Ann. New York Acad. Sci., 1995, vol. 771, pp. 535–550.

Cooper C. (Ed.). Handbook of Stress, Medicine, and Health. Boca Raton, CRC Press, 1996.

Cooper E. L. Stress, Immunity, and Aging. New York, M. Dekker, 1984.

Cornuţiu, G. (Ed.). Al 2-lea Congres Naţional de Psihiatrie „Tulburările nevrotice în actuala dinamică a factorilor de stres”. Volum lucrări. Capitolul IV. Vulnerabilitate, Oradea, RO. Ed. Imprimeriei de Vest,2003, pp. 213–291.

Cornuţiu G. Breviar de psihiatrie. Oradea, RO. Ed. Imprimeriei de Vest, 2008.

Cutler R. G., Rodriguez H. (Eds.). Critical Reviews of Oxidative Stress and Aging. Advances in Basic Science,Diagnostics and Intervention, vol. 1. River Edge, World Scientific, 2003.

Cutler R. G., Rodriguez H. (Eds.). Critical Reviews of Oxidative Stress and Aging. Advances in Basic Science, Diagnostics and Intervention, vol. 2. River Edge, World Scientific, 2003.

Dănăilă L., Popescu I., Păiş V., Riga D., Riga S., Păiş E. Apoptosis, paraptosis, necrosis, and cell regeneration in posttraumatic cerebral arteries. Chirurgia (Buc.), 2013, vol. 108, pp. 319–324.

Derevenco P., Anghel I., Băban A. Stresul în sănătate şi boală. De la teorie la practică. Cluj-Napoca, Ed.Dacia, 1992.

Derevenco P. Romanian scientific progress in international stress research and stress-aging medicine.Fiziologia-Physiology, 2006, vol. 16, pp. 9–14.

Fahy G. M., West M. D., Coles L. S., Harris S. B. (Eds.). The Future of Aging. Pathways to Human Life Extension. Dordrecht, Springer, 2010.

Finch C. E. Variations in senescence and longevity include the possibility of negligible senescence.J. Gerontol. Biol. Sci., 1998, vol. 53A, pp. 235–239.

Garcia J. H. Morphology of global cerebral ischemia. Crit. Care Med., 1989, vol. 16, pp. 979–987.

Garcia J. H., Anderson M. L. Circulatory disorders and their effects on the brain, In: R. L. Davis, D. M. Robertson (Eds.). Textbook of Neuropathology, 2nd ed. Baltimore, Williams & Wilkins, 1991,pp. 621–718.

Harman D. Free radical theory of aging and disease. Fiziologia-Physiology, 2004, vol. 14, pp. 4–6.

Kerr J. F. R., Wyllie A. H., Currie A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer., 1972, vol. 26, pp. 239–257.

Riegle G. D. Chronic stress effects on adrenocortical responsiveness in young and aged rats.Neuroendocrinology1973, vol. 11, pp. 1–10.

Riga S. Studii asupra Acizilor Nucleici din Sistemul Nervos Central în Procesele de Senescenţă. Bucureşti, Teză de Doctorat la Institutul de Medicină şi Farmacie. Bucureşti, 1976.

Riga D., Riga S. Mărirea vitalităţii creierului, factor în promovarea stării de sănătate mintală. Revista Sanitară Militară, 1979, vol. 82, pp. 421–431.

Riga D., Riga S., Schneider F. Regenerative medicine: Antagonic-Stress® therapy in distress and aging. I. Preclinical synthesis — 2003, In: A. D. N. J. de Grey (Ed.), Strategies for Engineered Negligible Senescence.Why Genuine Control of Aging May Be Foreseeable. Ann. New York Acad. Sci., 2004, vol. 1019,pp. 396–400.

Riga S., Riga D. (Eds.). Stresul şi societatea modernă. Revista Română de Sănătate Mintală, 2004,vol. 11, pp. 1–62.

Riga D., Riga S., Schneider F. Vulnerabilitate, stres şi îmbătrânire: dimensiunea antropologică a stresului în senescenţă. Revista Română de Sănătate Mintală, 2004, vol. 11, pp. 35–44.

Riga D., Riga S., Hălălău F., Schneider F. Lipofuscin and ceroid pigments — markers of normal and pathological brain aging, In: R. Klatz, R. Goldman (Eds), Anti-Aging Therapeutics, vol. 8. Chicago, American Academy of Anti-Aging Medicine, 2006, pp. 213–222.

Riga D., Riga S., Hălălău F., Schneider F. Neurono-glial mechanisms in brain protection, aging deceleration and neuro-psycho-longevity, In: R. Klatz, R. Goldman (Eds.), Anti-Aging Therapeutics, vol. 8. Chicago, American Academy of Anti-Aging Medicine, 2006, pp. 223–235.

Riga D., Riga S. O nouă paradigmă în medicină şi psihiatrie: tetrada disstres → uzură → îmbătrânire
→ polipatologie, In: G. Cornuţiu, D. Marinescu (Eds.), Orientări şi perspective în gândirea psihiatrică românească actuală, Vol. 1. Oradea, Ed. Universităţii din Oradea, 2007, pp. 31–75.

Riga D., Riga S. Medicina anti-îmbătrânire şi ştiinţele longevităţii. Bucureşti, Ed. Cartea Universitară(Ars Academica), 2007.

Riga S., Riga D. Stresologie, adaptologie şi sănătate mintală. Bucureşti, Ed. Cartea Universitară (Ars Academica), 2008.

Riga S., Riga D., Mihăilescu A., Motoc D., Moş L., Schneider F. Longevity health sciences and mental health as future medicine, In: R. M. Tanguay (Ed.), Aging, Cancer, and Age-Related Diseases. Common Mechanisms? Ann. New York Acad. Sci., 2010, vol. 1197, pp. 184–187.

Riga D., Riga S. Capitol 6. Medicina stresului — necesitate a prezentului, In: J. Vincze (Ed.), Biofizică Medicală (Medical Biophysics), Biophysics. Budapest, Ed. NDP, 2011, vol. 38, pp. 141–174.

Riga D., Riga S., Motoc D., Geacăr S., Ionescu T. Ch. 17. Health-longevity medicine in the global world, In: J. Maddock (Ed.), Public Health. Methodology, Environmental and Systemic Issues. Rijeka, Croatia and Shanghai, China, InTech — Open Access Publ, 2012, pp. 347–366.

Sapolsky R. M., Krey L. C., McEwen B. S. Corticosterone receptors decline in a site-specific manner in the aged rat brain. Brain Res., 1983, vol. 289, pp. 235–240.

Sapolsky R. M., Krey L. C., McEwen B. S. Prolonged glucocorticoid exposure reduced hippocampal neuron number: implication for aging. J. Neurosci., 1985, vol. 5, pp. 1222–1227.

Sapolsky R. M., Krey L. C., McEwen B. S. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr. Rev., 1986, vol. 7, pp. 284–301.

Sapolsky R. M., Packan D., Vale W. Glucocorticoid toxicity in the hippocampus: in vitro demonstration.Brain Res., 1988, vol. 453, pp. 367–371.

Selye H. The general adaptation syndrome and the diseases of adaptation. J. Clin. Endocrinol., 1946,vol. 6, pp. 117–230.

Selye H. Stress and aging. J. Am. Geriatr. Soc., 1970, vol. 18, pp. 669–680.

Selye H. The evolution of the stress concept. American Scientist, 1973, vol. 61, pp. 692–699.

Shader R. I., Harmatz J. S., Salzman C. A new scale for clinical assessment in geriatric populations:Sandoz Clinical Assessment-Geriatric (SCAG). J. Am. Geriatr. Soc., 1974, vol. 22, pp. 107–113.

Sigurdsson E. M., Calero M., Gasset M. (Eds.). Amyloid Proteins. Methods and Protocols. 3rd ed. New York, Springer-Humana Press, 2018.

Sloper J. J., Johnson P., Powell T. P. S. Selective degeneration of inter-neurons in the motor cortex of infant monkeys following controlled hypoxia: a posible cause of epilepsy. Brain Res., 1980, vol. 198,pp. 204–209.

Tang F., Phillips J. G. Some age-related changes in pituitary-adrenal function in the male laboratory rat.J. Gerontol., 1978, vol. 33, pp. 377–382.

Tatu C., Schneider F., Tatu F. R., Puşcaşiu D., Siska I., Brestoviceanu D. Molecular chaperones and protein misfolding in disease. Fiziologia-Physiology, 2000, vol. 10, pp. 3–9.

Wallace D. C., Shoffner J. M., Trounce I., Brown M. D., Ballinger S. W., Corral-Debrinski M., Horton T., Jun A. S., Lott M. T. Mitochondrial DNA mutations in human degenerative diseases and aging. Biochimica et Biophysica Acta, 1995, vol. 1271, pp. 141–151.

Watts D. L. Trace Elements and other Essential Nutrients. Clinical Applications of Tissue Mineral Analysis.Dallas, Trace Elements, 1995.

Wheatley D. The Wheatley stress profile.Stress Med., 1993, vol. 9, pp. 5–9.

Wheatley D. Stress, anxiety and depression. Stress Med., 1997, vol. 13, pp. 173–177.

Yesavage J. A., Adey M., Werner P. D. Development of a geriatric behavioural self-assessment scale.J. Am. Geriatr. Soc., 1981, vol. 29, pp. 285–288.

von Zglinicki, T. Telomeric damage in aging, In: T. von Zglinicki (Ed.), Aging at the Molecular Level.Dordrecht, Kluwer, 2003, pp. 121–129.
Опубликован
2019-11-14
Как цитировать
Riga, S., Budisteanu, M., Budisteanu, B., Dionisie, V., & Scripnic, V. V. (2019). Ageing Acceleration and Disease Onset: Ontogenetic Specificity of Pathogenetic Mechanisms. Вестник Санкт-Петербургского университета. Медицина, 14(2), 105–122. извлечено от https://medicine-journal.spbu.ru/article/view/4986
Раздел
Патологическая физиология