Growth hormone treatment strategies in assisted reproduction for the poor responder patients

Авторы

  • Liailia Kh. Dzhemlikhanova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Ksenia V. Ob’edkova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Dariko A. Niauri St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Igor Yu. Kogan St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Maria A. Mazilina St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Inna O. Krikheli Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Irina D. Mekina Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Elena A. Lesik Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation
  • Evgenia M. Komarova Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, 3, Mendeleevskaya liniya, St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.205

Аннотация

The goal of the study was to estimate the efficacy of growth hormone (GH) co-treatment to the antagonist protocol in IVF/ ICSI cycles in poor responders. A prospective observational study involved 75 patients. All patients underwent standard antagonist protocol with or without GH co-treatment. GH additional was given a daily subcutaneous injection of 1.33 mg (equivalent to 4 IU) of GH from day 1 of ovarian stimulation until the day of human chorionic gonadotropin (hCG). Concentrations of GH, insulin-like growth factor I (IGF-I) and IGF binding protein-3 (IGFBP-3) in serum and follicular fluid were analyzed. The GH co-treatment significantly lowered effective dose of gonadotropins, duration of stimulation, IGFBP-3 level in serum and follicular fluid day of oocytes retrieval. The number of oocytes recovered, metaphase II stage (MII) oocytes, 2 pronucleus (2 pn) zygote, good-quality transferred embryos were significantly higher in the GH+ group. Only patients GH+ group became pregnant. Positive correlation was found between IGF-I level in follicular fluid, dynamics of IGFBP-3 level changes during stimulation protocol and number of good-quality transferred embryos in the GH+ group. GH administration in IVF/ICSI cycles for poor responders raises ovarian sensitivity to the gonadotropin exogenous influence, this way, increasing number of high-quality embryos and the probability of pregnancy.

Ключевые слова:

growth hormone; poor ovarian response; in vitro fertilization (IVF); assisted reproductive technologies (ART)

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Загрузки

Опубликован

14.11.2019

Как цитировать

Dzhemlikhanova, L. K., Ob’edkova, K. V., Niauri, D. A., Kogan, I. Y., Mazilina, M. A., Krikheli, I. O., … Komarova, E. M. (2019). Growth hormone treatment strategies in assisted reproduction for the poor responder patients. Вестник Санкт-Петербургского университета. Медицина, 14(2), 132–140. https://doi.org/10.21638/spbu11.2019.205

Выпуск

Раздел

Акушерство и гинекология