Development of an immunoassay test system for diagnostics and differential diagnosis of autoimmune motility disorders of the gastrointestinal tract

Vera Lantsova; Elene  Sepp

doi:10.21638/spbu11.2019.427

Authors

Vera Lantsova Neuromed Medical Center, 17/1, Bolshoi Ovchinnikovsky per., Moscow, 115184, Russian Federation
Elene Sepp Neuromed Medical Center, 17/1, Bolshoi Ovchinnikovsky per., Moscow, 115184, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.427

Abstract

Gastrointestinal motility disorders associated with impaired intestinal innervation have been little studied. Disruptions in the work of parasympathetic and metasympathetic structures can be caused by an autoimmune process both against the receptor apparatus and against peptides that perform mediator functions. In this regard, the development of methods for determining antibodies to the α3-acetylcholine receptor and the gonadoliberin releasing factor, which are involved in the regulation of gastrointestinal motility is relevant. As shown in this article, detection of these autoantibodies in patients with gastrointestinal motility disorders allows one to diagnose autoimmune damage to the peripheral parasympathetic and metasympathetic division of the autonomic nervous system, to conduct differential diagnosis of clinically similar pathological processes and to provide adequate timely treatment aimed at suppressing autoimmune lesions of the autoimmune nervous system and improving the quality of life of patients with peripheral autonomic insufficiency.

Keywords:

autoimmune lesions, autonomic nervous system, ELISA, GnRH, α3-AсhR

Downloads

Download data is not yet available.

References

References

Maev I.V., Cheryomushkin S.V. Practical Gastroenterology. Irretated Bowel Syndrome: Guide for Physicians. Moscow, Forte print Publ., 2012. (In Russian)

Menzhinskaya I.V., Van’ko L.V., Kiryushchenkov P.A., Ter-Avanesov G.V., Gavrilov Y.A., Sukhikh G.T. Correlation between Antibodies to Gonadotropin-Releasing Hormone and Reproductive Disorders in Humans. Bull. Exp. Biol. Med., 2013, vol. 155, no. 6, pp. 715–717. (In Russian)

Lantsova V.B., Sepp E.K., Ionova V.G., Maximova M.Yu. Method of diagnosis of the autoimmune lesion of gut autonomic structures. Patent 2526812 of 02.07.2014. (In Russian)

Vemino S., Low P.A., Fealey R.D., Stewart J.D., Farrugia G., Lennon V.A. Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies. N. Engl. J. Med., 2000, vol. 343, pp. 847–855.

Ohlsson B., Veress B., Janciauskiene S., Montgomery A., Haglund M., Wallmark A. Chronic intestinal pseudo-obstruction due to buserelin-induced formation of anti-GnRH antibodies. Gastroenterology,2007, vol. 132, pp. 45–51.