МОРФОЛОГИЧЕСКИЕ ИЗМЕНЕНИЯ ЗРИТЕЛЬНОГО АНАЛИЗАТОРА И НАРУШЕНИЕ ЗРИТЕЛЬНО-ПРОСТРАНСТВЕННОГО ВОСПРИЯТИЯ ПРИ БОЛЕЗНИ ПАРКИНСОНА

Игорь Вячеславович Литвиненко; Эрнест Витальевич Бойко; Павел Сергеевич Дынин; Богдан Сергеевич Литвинцев; Артем Геннадьевич Труфанов; Владимир Юрьевич Лобзин; Валентин Игоревич Леонов; Елена Валентиновна Литвиненко; Рифат Фаатович Гимадутдинов; Антон Александрович Юрин

doi:10.21638/11701/spbu11.2016.303.

Authors

Игорь Вячеславович Литвиненко Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Эрнест Витальевич Бойко Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Павел Сергеевич Дынин Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Богдан Сергеевич Литвинцев Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Артем Геннадьевич Труфанов Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Владимир Юрьевич Лобзин Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Валентин Игоревич Леонов Saint Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Елена Валентиновна Литвиненко Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Рифат Фаатович Гимадутдинов Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation
Антон Александрович Юрин Military Medical Academy named after S. M. Kirov, 6, Academic Lebedev str., St. Petersburg, 194044, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2016.303.

Abstract

Modern data about the etiopathogenesis of the considered symptoms is represented. The results of our own research with estimation of the thickness of the various layers of the retina, the cerebral cortex, clinical and neuropsychological examination of patients are presented. Examination of the retina and the thickness of the cerebral cortex were carried out using the technique of optical coherent tomography and magnetic resonance imaging of the brain, respectively. Clinical and neuropsychological testing, aimed at setting the degree of severity of the disease, the severity of visual-spatial and cognitive changes and their relationship were conducted. The data allow us to view the presence of the most sensitive areas of the retina and cerebral cortex in the development of visual-spatial impairment in Parkinson’s disease patients. Refs 37. Figs 3. Tabl. 4.

Keywords:

Parkinson’s disease, visual-spatial disorders, cognitive disorders, retina, morphometry, optical coherence tomography

Downloads

Download data is not yet available.

References

Литература

Иллариошкин С. Н. Течение болезни Паркинсона и подходы к ранней диагностике // Болезнь Паркинсона и расстройства движений: Руководство для врачей по материалам II Национального конгресса. М.: НЦН РАМН, 2011. С. 41–47.

Литвиненко И. В., Одинак М. М., Труфанов А. Г. Болезнь Паркинсона и синдромы паркинсонизма: Методические рекомендации. СПб.: ЭЛБИ-СПб, 2012.

Нодель М. Р., Яхно Н. Н. Нервно-психические нарушения при болезни Паркинсона // Неврология, нейропсихиатрия, психосоматика. 2009. № 2. С. 3–8.

Archibald N. K., Clarke M. P., Mosimann U. P., Burn D. J. The retina in Parkinson’s disease // Brain. 2009. No 132. Р. 1128–1145.

Biousse V., Skibell B. C., Watts R. L. et al. Ophthalmologic features of Parkinson’s disease // Neurology.2004. No 62. Р. 177–180.

Davidsdottir S., Cronin-Golomb A., Lee A. Visual and spatial symptoms in Parkinson’s disease // Vision Res. 2005. No 45. Р. 1285–1296.

Левин О. С., Федорова Н. В. Болезнь Паркинсона. 2-е изд. М.: МЕД Пресс-Информ, 2012. 352 с.

Иллариошкин С. Н. Когнитивные расстройства. Ранние (додементные) формы когнитивных расстройств // Consilium Medicum. 2007. Т. 9 (7). С. 9–15.

Литвиненко И. В., Одинак М. М. Патогенетические основы формирования когнитивных и психотических нарушений при болезни Паркинсона // Журнал неврологии и психиатрии им. С. С. Корсакова. 2004. Т. 104 (4). С. 76–80.

Литвиненко И. В. Деменция и психотические нарушения при паркинсонизме: общность возникновения и новые перспективы в терапии // Успехи геронтологии. 2004. № 13. С. 94–101.

Литвиненко И. В., Одинак М. М., Шатова А. В., Сологуб О. С. Структура когнитивных нарушений на разных стадиях болезни Паркинсона // Вестник Российской Военно-медицинской академии. 2007. Т. 3 (19). С. 43–49.

Литвиненко И. В. Некогнитивные предикторы деменции при болезни Паркинсона // Болезнь Паркинсона и расстройства движений: Руководство для врачей по материалам III Национального конгресса. М.: РКИ «Соверо-Пресс», 2014. С. 86–89.

Литвиненко И. В., Труфанов А. Г., Юрин А. А., Резванцев М. В., Воронков Л. В., Фокин В. А. Морфометрические основы депрессии при болезни Паркинсона и возможности ее прогнозирования // Доктор.Ру. 2014. № 6–1 (94). С. 20–25.

Archibald N. K., Clarke M. P., Mosimann U. P., Burn D. J. Visual symptoms in Parkinson’s disease and Parkinson’s disease dementia // Movement disorders. 2011. No 26(13). Р. 2387–2395.

Tian T., Zhu X.-H., Liu Y.-H. Potential role of retina as a biomarker for progression of Parkinson’s disease // International Journal of Ophthalmology 2011. No 4 (4). Р. 433–438.

Lee J. Y., Kim J. M., Ahn J. et al. Retinal nerve fiber layer thickness and visual hallucinations in Parkinson‘s Disease // Movement Disorders. 2014. No 29 (1). Р. 61–67.

Litvan I., Goldman J. G., Tröster A. I. et al. Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines // Movement Disorders. 2012. No 27. Р. 349–356.

Svenningsson P., Westman E., Ballard C., Aarsland D. Cognitive impairment in patients with Parkinson’s disease: diagnosis, biomarkers, and treatment // Lancet Neurol. 2012. No 11. Р. 697–707.

Williams-Gray C. H., Evans J. R., Goris A. et al. The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort // Brain. 2009. No 132. Р. 2958–2969.

Frederick J. M., Rayborn M. E., Laties A. M. et al. Dopaminergic neurons in the human retina // Comp. Neurol. 1982. No 210 (1). Р. 65–79.

Nguyen-Legros J. Functional neuroarchitecture of the retina: hypothesis on the dysfunction of retinal dopaminergic circuitry in Parkinson’s disease // Surg. Radiol. Anat. 1988. No 10. Р. 137–144.

Aaker G. D., Myung J. S., Ehrlich J. R. et al. Detection of retinal changes in Parkinson’s disease with spectral-domain optical coherence tomography // Clin. Ophthalmol. 2010. No 4. Р. 1427–1432.

Archibald N. K., Clarke M. P., Mosimann U. P., Burn D. J. Retinal thickness in Parkinson’s disease // Parkinsonism Relat. Disord. 2011. No 17. Р. 431–436.

Cubo E., Tedejo R. P., Rodriguez Mendez V. et al. Retina thickness in Parkinson’s disease and essential tremor // Movement Disorders. 2010. No 25 (14). Р. 2461–2462.

Бойко Э. В., Коваленко А. В., Бисага Г. Н., Краснощекова Е. Е. Роль оптической когерентной томографии в диагностике и лечении демиелинизирующих заболеваний // Офтальмологические ведомости. 2010. Т. 3 (1). С. 4–10.

Одинак М. М., Емелин А. Ю., Лобзин В. Ю., Воробьев С. В., Киселев В. Н. Современные возможности нейровизуализации в дифференциальной диагностике когнитивных нарушений // Неврология, нейропсихиатрия, психосоматика. 2012. Спецвыпуск 2. С. 51–55.

Gibb W. R., Less A. J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease // J. Neurol. Neurosurg. Psychiatry. 1988. No 51 (6). Р. 745–752.

Hughes A. J., Daniel S. E., Kilford L. et al. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases // J. Neurol. Neurosurg. Psychiatry. 1992. No 55 (3). Р. 181–184.

Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality // Neurology 1967. No 17 (5). Р. 427–442.

Dubois B., Slachevsky A., Litvan I., Pillon B. The FAB: Frontal Assessment Battery at bedside // Neurology. 2000. No 55. Р. 1621–1626.

Emre M., Arsland D., Brown R. et al. Clinical diagnostic criteria for dementia associated with Parkinson’s disease // Movement Disorders 2007. No 15 (22). Р. 1689–1707.

Fahn S., Elton R. L. UPDRS Development Committee. The Unified Parkinson’s Disease Rating Scale // Recent Developments in Parkinson’s Disease / eds. S. F ahn, C. D. Marsden, D. B . Calne, M. G oldstein. 2 ed. New Jersey: Macmillan Healthcare Information, 1987. Р. 293–304.

Folstein M. F., Folstein S. E., McHugh P. R. «Mini-mental state». A practical method for grading the cognitive state of patients for the clinican // Journal of psychiatric research. 1975. No 12. Р. 189–198.

Лурия А. Р. Высшие корковые функции человека. СПб.: Питер, 2008. 624 с.

Curcio C. A.Photoreceptor topography in ageing and age-related maculopathy // Eye. 2001. No 15. Р. 376–383.

Селивёрстов Ю. А., Селивёрстова Е. В., Коновалов Р. Н., Клюшников С. А., Кротенкова М. В., Иллариошкин С. Н. Функциональная магнитно-резонансная томография покоя и ее роль в изучении экстрапирамидных заболеваний // Болезнь Паркинсона и расстройства движений: Руководство для врачей по материалам III Национального конгресса. М.: РКИ «Соверо-Пресс», 2014. С. 138–142.

Тютин Л. А., Поздняков А. В., Станжевский А. А., Литвиненко И. В. Роль протонной магнитно-резонансной спектроскопии в комплексной диагностике болезни Паркинсона // Медицинская визуализация. 2006. № 4. С. 105–111.

References

Illarioshkin S. N. [Course of Parkinson’s disease and approaches to early diagnosis]. Bolezn’ Parkinsona i rasstroistva dvizhenii: Rukovodstvo dlia vrachei po materialam II Natsional’nogo kongressa [Parkinson’s disease and movement disorders: Guide for physicans on materials of II National congress]. Moscow, NCN RAMS Publ., 2011, pp. 41–47. (In Russian)

Litvinenko I. V., Odinak M. M., Trufanov A. G . Bolezn’ Parkinsona i sindromy parkinsonizma. Metodicheskie rekomendatsii [Parkinson’s disease and syndroms of parkinsonism. Guidline]. Saint Petersburg,ELBI-SPb Publ., 2012. (In Russian)

Nodel M. R., Yakhno N. N. Nervno-psikhicheskie narusheniia pri bolezni Parkinsona [Neuropsychical defects at Parcinson’s disease]. Neurology, neuropsychiatry, psychosomatics, 2009, vol. 2, pp. 3–8. (In Russian)

Archibald N. K., Clarke M. P., Mosimann U. P., Burn D. J. The retina in Parkinson’s disease. Brain,2009, no. 132, pp. 1128–1145.

Biousse V., Skibell B. C., Watts R. L. et al. Ophthalmologic features of Parkinson’s disease. Neurology,2004, no. 62, pp. 177–180.

Davidsdottir S., Cronin-Golomb A., Lee A. Visual and spatial symptoms in Parkinson’s disease. Vision Res, 2005, no. 45, pp. 1285–1296.

Levin O. S., Fedorova N. V. Bolezn’ Parkinsona [Parkinson’s disease]. 2nd ed. Moscow, MED Press-Inform, 2012. 352 p. (In Russian)

Illarioshkin S. N. Kognitivnye rasstroistva. Rannie (dodementnye) formy kognitivnykh rasstroistv [Cognitive disorders. Early (predemention) forms of cognitive impairments]. Consilium Medicum, 2007, vol. 9 (7), pp. 9–15. (In Russian)

Litvinenko I. V., Odinak M. M. Patogeneticheskie osnovy formirovaniia kognitivnykh i psikhoticheskikh narushenii pri bolezni Parkinsona [Pathogenesis basics of elaboration cognitive and psychical disorders at Parkinson’s disease]. The Korsakov’s Journal of Neurology and Psychiatry, 2004, vol. 104 (4), pp. 76–80. (In Russian)

Litvinenko I. V. Dementsiia i psikhoticheskie narusheniia pri parkinsonizme: obshchnost’ vozniknoveniia i novye perspektivy v terapii [Dementia and psychotic disorders in parkinsonism: common genesis and new perspective of treatment]. Advances in gerontology, 2004, vol. 13, pp. 94–101. (In Russian)

Litvinenko I. V., Odinak M. M., Shatova А. V., Sologub О. S. Struktura kognitivnykh narushenii na raznykh stadiiakh bolezni Parkinsona [Structure of cognitive impairments in different stages of Parkinson’s disease]. Mercury of Russian Military-medical academy, 2007, vol. 3 (19), pp. 43–49. (In Russian)

Litvinenko I. V. [Noncognitive predictors of dementia in Parkinson’s disease]. Bolezn’ Parkinsona i rasstroistva dvizhenii: Rukovodstvo dlia vrachei po materialam III Natsional’nogo kongressa [Parkinson’s disease and movement disorders: Guide for physicians by materials of III National congress]. Мoscow, RKI «Sovero-Press», 2014, pp. 86–89. (In Russian)

Litvinenko I. V., Trufanov А. G ., Yurin А. А., Rezvancev М. V., Voronkov L. V., Fokin V. А. Morfometricheskie osnovy depressii pri bolezni Parkinsona i vozmozhnosti ee prognozirovaniia [Depression in Parkinson’s Disease: Morphometric Findings and Prognostic Options]. Doctor.ru, 2014, vol. 6–1 (94),pp. 20–25. (In Russian)

Archibald N. K., Clarke M. P., Mosimann U. P., Burn D. J. Visual symptoms in Parkinson’s disease and Parkinson’s disease dementia. Movement disorders, 2011, no. 26(13), pp. 2387–2395.

Tian T., Zhu X.-H., Liu Y.-H. Potential role of retina as a biomarker for progression of Parkinson’s disease. International Journal of Ophthalmology, 2011, no. 4 (4), pp. 433–438.

Lee J. Y ., Kim J. M., Ahn J. et al. Retinal nerve fiber layer thickness and visual hallucinations in Parkinson‘s Disease. Movement Disorders, 2014, no. 29 (1), pp. 61–67.

Litvan I., Goldman J. G ., Tröster A. I. et al. Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines. Movement Disorders, 2012, no. 27,pp. 349–356.

Svenningsson P., Westman E., Ballard C., Aarsland D. Cognitive impairment in patients with Parkinson’s disease: diagnosis, biomarkers, and treatment. Lancet Neurol., 2012, no. 11, pp. 697–707.

Williams-Gray C. H ., Evans J. R., Goris A. et al. The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort. Brain, 2009, no. 132, pp. 2958–2969.

Frederick J. M., Rayborn M. E., Laties A. M. et al. Dopaminergic neurons in the human retina. Comp. Neurol., 1982, no. 210 (1), pp. 65–79.

Nguyen-Legros J. Functional neuroarchitecture of the retina: hypothesis on the dysfunction of retinal dopaminergic circuitry in Parkinson’s disease. Surg. Radiol. Anat., 1988, no. 10, pp. 137–144.

Aaker G. D., Myung J. S., Ehrlich J. R. et al. Detection of retinal changes in Parkinson’s disease with spectral-domain optical coherence tomography. Clin. Ophthalmol., 2010, no. 4, pp. 1427–1432.

Archibald N. K., Clarke M. P., Mosimann U. P., Burn D. J. Retinal thickness in Parkinson’s disease. Parkinsonism Relat. Disord., 2011, no. 17, pp. 431–436.

Cubo E., Tedejo R. P., Rodriguez Mendez V. et al. Retina thickness in Parkinson’s disease and essential tremor. Movement Disorders, 2010, no. 25 (14), pp. 2461–2462.

Boiko E. V., Kovalenko А. V., Bisaga G. N., Krasnoschekova Е. Е. Rol’ opticheskoi kogerentnoi tomografii v diagnostike i lechenii demieliniziruiushchikh zabolevanii [Role of optical coherent tomography in diagnosis and treatment demyelinating diseases]. Ophthalmological journal, 2010, vol. 3 (1), pp. 4–10. (In Russian)

Odinak M. M., Emelin А. Y ., Lobzin V. Y ., Vorobyev S. V., Kiselev V. N. Sovremennye vozmozhnosti neirovizualizatsii v differentsial’noi diagnostike kognitivnykh narushenii [Current capacities for neuroimaging in the differential diagnosis of cognitive impairments]. Neurology, Neuropsychiatry, Psychosomatics, 2012. 4(2S), pp. 51–55. (In Russian)

Gibb W. R., Less A. J. The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry, 1988, no. 51 (6), pp. 745–752.

Hughes A. J., Daniel S. E., Kilford L. et al. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry, 1992, no. 55 (3), pp. 181–184.

Hoehn M. M., Yahr M. D. Parkinsonism: onset, progression and mortality. Neurology, 1967, no. 17 (5),pp. 427–442.

Dubois B., Slachevsky A., Litvan I., Pillon B. The FAB: Frontal Assessment Battery at bedside.Neurology,2000, no. 55, pp. 1621–1626.

Emre M., Arsland D., Brown R. et al. Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Movement Disorders, 2007, no. 15 (22), pp. 1689–1707.

Fahn S., Elton R. L. UPDRS Development Committee. The Unified Parkinson’s Disease Rating Scale. Recent Developments in Parkinson’s Disease. Eds. S. Fahn, C. D. Marsden, D. B. Calne, M. Goldstein. 2 ed. New Jersey, Macmillan Healthcare Information, 1987, pp. 293–304.

Folstein M. F ., Folstein S. E., McHugh P. R. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinican. Journal of psychiatric research, 1975, no. 12, pp. 189–198.

Luria А. R. Vysshie korkovye funktsii cheloveka [Higher cortical functions in man]. Saint Petersburg, Piter Publ., 2008. 624 p. (In Russian)

Curcio C. A. Photoreceptor topography in ageing and age-related maculopathy. Eye, 2001, no. 15, pp. 376–383.

Seliverstov Y. А., Seliverstova Е. V., Konovalov R. N., Klyushnikov S. А., Krotenkova М. V., Illarioshkin S. N. [The role of functional magnetic resonance imaging in research of extrapyramidal disorders]. Bolezn’ Parkinsona i rasstroistva dvizhenii: Rukovodstvo dlia vrachei po materialam III Natsional’nogo kongressa [Parkinson’s disease and movement disorders: Guide for physicians by materials of III National congress].Мoscow, RKI “Sovero-Press”, 2014, pp. 138–142. (In Russian)

Tyutin L. А., Pozdnyakov А. V., Stanjevskyi А. А., Litvinenko I. V. Rol’ protonnoi magnitno-rezonansnoi spektroskopii v kompleksnoi diagnostike bolezni Parkinsona [The role of proton magnetic resonance imaging in complex diagnosis of Parkinson’s disease]. Medical visualization, 2006, vol. 4, pp. 105–111. (In Russian)