ВЛИЯНИЕ ПОЛИМОРФИЗМА ГЕНОВ СЕРОТОНИН- И ДОФАМИНЭРГИЧЕСКИХ СИСТЕМ НА УРОВЕНЬ КОГНИТИВНЫХ И НЕЙРОДИНАМИЧЕСКИХ ФУНКЦИЙ В ЭКСТРЕМАЛЬНЫХ УСЛОВИЯХ ПРОФЕССИОНАЛЬНОЙ ДЕЯТЕЛЬНОСТИ

Александр Олегович Пятибрат; Сергей Борисович Мельнов; Алексей Викторович Балахонов; Сергеевна Анна Козлова; Елена Дмитриевна Пятибрат; Петр Дмитриевич Шабанов

Authors

Александр Олегович Пятибрат Th e Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, 4/2, ul. Academica Lebedeva, St. Petersburg, 194044, Russian Federation
Сергей Борисович Мельнов Международный государственный экологический университет им. А. Д. Сахарова, Республика Беларусь, 220070, Минск, ул. Долгобродского, 23
Алексей Викторович Балахонов St. Petersburg State University, 7/9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
Сергеевна Анна Козлова International Sakharov Environmental University, 23, ul. Dolgobrodskaya, Minsk, 220070, Belarus
Елена Дмитриевна Пятибрат Kirov military medical academy, 6, ul. Academica Lebedeva, St. Petersburg, 194044, Russian Federation
Петр Дмитриевич Шабанов Kirov military medical academy, 6, ul. Academica Lebedeva, St. Petersburg, 194044, Russian Federation

Abstract

To assess changes in neurodynamic and cognitive functions associated with extreme exercise loads depending on gene polymorphism which regulates cerebral monoamic system, military men were examined. It is shown that the most informative techniques to assess changes in cognitive functions are “Arithmetic count” and “Conformity establishment”. Th e results of the examination stated that people with COMT Val/Val genotypes demonstrated evidently higher cognitive fl exibility aft er extreme exercise loads at performing combat training tasks than those with alleles COMT Met. Th e most reliable results of changes in neurodynamic functions were obtained using techniques “Reaction to the moving object” and “Landolt’s rings visual acuity test”. Military men with genotypes 5HTT S/S, 5HT2A C/C and DRD2 A1/A1 demonstrated the best indices aft er extreme exercise loads than those with alleles 5HTT L, 5HT2A T, DRD2 A2. Using methods of genetic screening allows a signifi cant increase of prognostic selection and evaluation of specialists’ abilities necessary for the effi cient activity in extreme conditions within the stated above forces. It was shown that gene analysis 5HTT, 5HT2A, DRD2 and COMT is signifi cant at professional selection of the candidates to use diffi cult ergonomic systems at performing combat tasks.

Keywords:

military, extreme activity, gene polymorphism, molecular genetics, physical endurance, current mental state, cognitive function, neural function

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References

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