СУБКЛИНИЧЕСКОЕ ВЫДЕЛЕНИЕ ВИРУСОВ ЭПШТЕЙНА—БАРР И ИММУНИТЕТ ПРИ ГЕНИТАЛЬНОМ ГЕРПЕСЕ У ЖЕНЩИН

Дмитрий Константинович Ермоленко; Анна Васильевна Закревская; Ирина Робертовна Желтакова; Константин Дмитриевич Ермоленко; Валерий Александрович Исаков; Дмитрий Валерьевич Исаков; Наталья Георгиевна Рощина

doi:10.21638/11701/spbu11.2017.408

Authors

Дмитрий Константинович Ермоленко Pasteur Institute of Epidemiology and Microbiology, 14, ul. Mira, St. Petersburg, 197101, Russian Federation
Анна Васильевна Закревская Pasteur Institute of Epidemiology and Microbiology, 14, ul. Mira, St. Petersburg, 197101, Russian Federation
Ирина Робертовна Желтакова Pasteur Institute of Epidemiology and Microbiology, 14, ul. Mira, St. Petersburg, 197101, Russian Federation
Константин Дмитриевич Ермоленко Pasteur Institute of Epidemiology and Microbiology, 14, ul. Mira, St. Petersburg, 197101, Russian Federation ; Pediatric Research and Clinical Center for Infectious Diseases, 9, ul. Professora Popova, St. Petersburg, 197022, Russian Federation
Валерий Александрович Исаков Pavlov First St. Petersburg-State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
Дмитрий Валерьевич Исаков Pavlov First St. Petersburg-State Medical University, 6–8, ul. L’va Tolstogo, St. Petersburg, 197022, Russian Federation
Наталья Георгиевна Рощина Pasteur Institute of Epidemiology and Microbiology, 14, ul. Mira, St. Petersburg, 197101, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu11.2017.408

Abstract

The aim of the study was to study the incidence of asymptomatic determination of Epstein-Barr viruses (EBV) in women with genital herpes (GH) with a recurring course of the disease depending on the stage of the process of infection and the state of vaginal microbiota. It was shown that, in the case of a severe course of GH, this phenomenon is observed both with recurrence of the disease (28 % of cases) and remission (18 % of cases). This is facilitated by the immune response that forms in patients with Th2 type. With an average course of GH during remission, but against a background of bacterial vaginosis (BV), VEB is isolated in 23 % of cases, and after its treatment in 8 %. This is explained by the Th2 type of immune response, and the lack of local antiviral immunity in BV. It was shown that a decrease in the intensity of the local and general antiviral immune response is able to “include” the mechanism of asymptomatic VEB secretion. Refs 23. Figs 6. Tables 2.

Keywords:

Epstein—Barr viruses, genital herpes, bacterial vaginosis, general and local immunity

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References

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