Gene polymorphism and professional activity as risk factors for the development of arterial hypertension

Authors

  • Natalia Golovanova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation;North-Western State Medical University named after I.I.Меchnikov, 47, Piskaryovsky pr., St. Petersburg, 195067, Russian Federation
  • Irina Astratenkova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Irina Lukyanova St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; North-Western State Medical University named after I.I.Меchnikov, 47, Piskaryovsky pr., St. Petersburg, 195067, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2023.101

Abstract

The leading cause of death in the modern world is chronic non-infectious diseases, and the leading metabolic risk factor is high blood pressure. At present, the role of reactive oxygen species in the development of arterial hypertension is well known, and the influence of epigenetic factors, such as social environment, daily routine, nutrition, in combination with genetic predisposition, is an important area of study also. The aim of our study was to identify the frequency of occurrence of polymorphic variants of the arterial hypertension marker gene angiotensinogen (rs4762) in combination with polymorphisms of the genes of enzymes of the antioxidant system: superoxide dismutase 2 (rs4880), and catalase (rs1001179) in emergency doctors, suffering from arterial hypertension. 20 patients participated in the study in whom the diagnosis of hypertension was established prior to inclusion in the study. Deoxyribonucleic acid DNA was isolated from epithelial cells of the oral cavity. Genotyping of samples was performed by real-time polymerase chain reaction. According to the results of our study, the AGT TT variant was not identified in this group, AGT CT was found only in 5 people. In other cases (75%), the development of the disease is not associated with the presence of an unfavorable allele of this gene. At the same time, 50% of those examined by us revealed the presence of an unfavorable T allele of the catalase gene and 80% of the T allele of the superoxide dismutase 2 gene. Considering that the professional activity of emergency doctors is one of the risk factors for the development of arterial hypertension, the presence of a high percentage of unfavorable alleles of antioxidant system enzymes in their genomes that we have identified indicates an increase in the
personal risk of this disease.

Keywords:

arterial hypertension, genetic polymorphism, angiotensinogen, superoxide dismutase, catalase

Downloads

Download data is not yet available.
 

References

Литература

Конради А. О. Современные представления о генетике артериальной гипертензии — мозаичная теория, гены-кандидаты, моногенные формы и широкогеномные исследования// Артериальная гипертензия. 2020. Т. 26, № 5. С. 490–500. https://doi.org/10.18705/1607-419X-2020-26-5-490-500

Александрова Л. А., Субботина Т. Ф., Жлоба А. А. Взаимосвязь дефицита фолатов, гипергомоци-стеинемии и метаболизма глутатиона у больных артериальной гипертензией // Артериальная гипертензия. 2020. Т. 26, № 6. С. 656–664. https://doi.org/10.18705/1607-419X-2020-26-6-656-664

Cафроненко А. В., Ганцгорн Е. В. Эндотелиальная дисфункция при рефрактерной артериальной гипертензии // Южно-Российский журнал терапевтической практики. 2021. Т. 2, № 2. С. 26–33.https://doi.org/10.21886/2712-8156-2021-2-2-26-33

Sousa T., Oliveira S., Afonso J., Morato M., Patinha D., Fraga S., Carvalho F., Albino-Teixeira A. Role of H2O2 in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II // British Journal of Pharmacology. 2012. Vol. 166, no. 8. P. 2386–2401. https://doi.org/10.1111/j.1476-5381.2012.01957.x

Маскова Г. С., Хохлов А. Л., Сироткина А. М. Полиморфизм генов артериальной гипертензии у детей с ожирением и артериальной гипертензией // Качественная клиническая практика.2020. № 5. С. 70–79. https://doi.org/10.37489/2588-0519-2020-5-70-79

Nadif R., Mintz M., Jedlicka A., Bertrand J.-P., Kleeberger S. R., Kauffmann F. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli // Free Radical Res. 2005. Vol. 39, no. 12. P. 1345–1350.

Брагина Е. Ю., Гончарова И. А., Фрейдин М. Б., Жалсанова И. Ж., Гомбоева Д. Е., Немеров Е. В., Пузырев В. П. Гаплотипический анализ генов CAT, TLR4 и IL10 у больных бронхиальной астмой с сопутствующей артериальной гипертензией // Сибирский научный медицинский журнал.2019. Т. 39, № 6. С. 55–64. https://doi.org/10.15372/SSMJ20190607

Ершова О. А., Баирова Т. А. Распространенность полиморфизма -262С/Т гена каталазы (rs1001179) у русских и бурят Восточной Сибири с эссенциальной артериальной гипертензией // Acta Biomedica Scientifica. 2015. № 3. С. 70–73.

Первушина О. А., Баирова Т. А., Колесникова Л. И. Полиморфизм Ala16Val гена супероксиддис-мутазы 2 (SOD2) у подростков-европеоидов с эссенциальной артериальной гипертензией, проживающих в Восточной Сибири // Acta Biomedica Scientifica. 2014. № 6. С. 111–114.

Иванов Н. В., Фогт С. Н., Худякова Н. В. Артериальная гипертензия с позиций нейроим-муноэндокринологии // Артериальная гипертензия. 2014. Т. 20, № 5. С. 349–354. https://doi.org/10.18705/1607-419X-2014-20-5-349-354


References

Konradi A. O. Current knowledge in hypertension genetics: mosaic theory, candidate genes and genome-wide association studies. Arterial’naia Gipertenziia, 2020, vol. 26, no. 5, pp. 490–500. https://doi.org/10.18705/1607-419X-2020-26-5-490-500 (In Russian)

Aleksandrova L. A., Subbotina T. F., Zhloba A. A. The relationship of folate deficiency, hyperhomocysteinemia and glutathione metabolism in hypertensive patients. Arterial’naia Gipertenziia, 2020, vol.26,no. 6, pp. 656–664. https://doi.org/10.18705/1607-419X-2020-26-6-656-664 (In Russian)

Safronenko A. V., Gantsgorn E. V. Endothelial dysfunction at refractory arterial hypertension. South Russian Journal of Therapeutic Practice, 2021, vol. 2, no. 2, pp. 26–33. https://doi.org/10.21886/2712-8156-2021-2-2-26-33 (In Russian)

Sousa T., Oliveira S., Afonso J., Morato M., Patinha D., Fraga S., Carvalho F., Albino-Teixeira A. Role of H2O2 in hypertension, renin-angiotensin system activation and renal medullary disfunction caused by angiotensin II. British Journal of Pharmacology, 2012, vol. 166, no. 8, pp. 2386–2401. https://doi.org/10.1111/j.1476-5381.2012.01957.x

Maskova G. S., Khokhlov A. L., Sirotkina A. M. Polymorphism of genes of arterial hypertension among children with obesity and arterial hypertension. Good Clinical Practice, 2020, no. 5, pp. 70–79. https://doi.org/10.37489/2588-0519-2020-5-70-79 (In Russian)

Nadif R., Mintz M., Jedlicka A., Bertrand J.-P., Kleeberger S. R., Kauffmann F. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. Free Radical Res., 2005, vol. 39, no. 12, pp. 1345–1350.

Bragina E. Y., Goncharova I. A., Freidin M. B., Zhalsanova I. Z., Gomboeva D. E., Nemerov E. V., Puzyrev V. P. Analysis of haplotypes of CAT, TLR4, and IL10 genes in bronchial asthma patients comorbid with arterial hypertension. The Siberian scientific medical journal, 2019, vol. 39, no. 6, pp. 55–

https://doi.org/10.15372/SSMJ20190607 (In Russian)

Ershova O. A., Bairova T. A. Polymorphism -262C/T of catalase gene (rs1001179) in Russian and Buryat populations with essential hypertension living in the Eastern Siberia. Acta Biomedica Scientifica, 2015, no. 3, pp. 70–73. (In Russian)

Pervushina O. A., Bairova T. A., Kolesnikova L. I. Ala16Val polymorphism of superoxidedismutase 2 (SOD2) gene in caucasoid teenagers with hypertension, living in the eastern siberia. Acta Biomedica Scientifica, 2014, no. 6, pp. 111–114. (In Russian)

Ivanov N. V., Fogt S. N., Khudyakova N. V. Neuroimmunoendocrinological aspects of arterial hypertension.Arterial’naia Gipertenziia, 2014, vol. 20, no. 5, pp. 349–354. https://doi.org/10.18705/1607-419X-2014-20-5-349-354 (In Russian)

Downloads

Published

2023-06-15

How to Cite

Golovanova, N., Astratenkova, I. ., & Lukyanova, I. . (2023). Gene polymorphism and professional activity as risk factors for the development of arterial hypertension. Vestnik of Saint Petersburg University. Medicine, 18(1), 4–11. https://doi.org/10.21638/spbu11.2023.101

Issue

Vol. 18 No. 1 (2023)

Section

Internal medicine

License

Articles of "Vestnik of Saint Petersburg University. Medicine" are open access distributed under the terms of the License Agreement with Saint Petersburg State University, which permits to the authors unrestricted distribution and self-archiving free of charge.