Transgenic animal models in translational biomedicine

Авторы

  • Рауль Гайнетдинов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation https://orcid.org/0000-0003-2951-6038

DOI:

https://doi.org/10.21638/spbu11.2019.404

Аннотация

Recent revolutionary transgenic approaches have significantly increased the power of translational biomedical research. For instance, genetic animal models of brain disorders such as schizophrenia, bipolar disorder, depression, Parkinson’s disease and attention deficit hyperactivity disorder have been created. Such animal models are the valuable tools for the study of aetiology and pathogenesis of human disorders, as well as for the early pre-clinical drug development in pharmacology. In this article the advantages of transgenic mouse and rat models for studying and modeling human disease are reviewed. At the Saint Petersburg University there is a library of the most relevant animal models of neuropsychiatric disorders, including mice lacking the dopamine transporter (DAT-KO mice) and rats without brain serotonin (tryptophan hydroxylase 2 knockout, TPH2-KO). This collection of psychopharmacologyrelevant mutant models is planned to be routinely used in future collaborative studies with Russian and international drug development institutions and companies.

 

Ключевые слова:

disease modeling, knockout animals, knock-in animals, transgene techniques, mice, rats, Psychopharmacology, dopamine, trace amines

Скачивания

Данные скачивания пока недоступны.
 

Библиографические ссылки


References

Efimova E.V., Gainetdinov R.R., Budygin E.A., Sotnikova T.D. Dopamine transporter mutant animals: a translational perspective. J. Neurogenet., 2016, vol. 30, no. 1, pp. 5–15.

Leo D., Sukhanov I., Zoratto F., Illiano P., Caffino L., Sanna F., Messa G., Emanuele M., Esposito A.,Dorofeikova M., Budygin E.A., Mus L., Efimova E.E., Niello M., Espinoza S., Sotnikova T.D., Hoener M.C., Laviola G., Fumagalli F., Adriani W., Gainetdinov R.R. Pronounced hyperactivity, cognitive dysfunctions and BDNF dysregulation in dopamine transporter knockout rats. J. Neurosci., 2018, vol.38, pp. 1959–1972.

Gainetdinov R.R., Hoener M.C., Berry M.D. Trace Amines and Their Receptors. Pharmacological Reviews, 2018, vol. 70, pp. 549–620.

Загрузки

Опубликован

15.06.2020

Как цитировать

Гайнетдинов, . Р. . (2020). Transgenic animal models in translational biomedicine. Вестник Санкт-Петербургского университета. Медицина, 14(4), 277–279. https://doi.org/10.21638/spbu11.2019.404

Выпуск

Раздел

Патологическая физиология