Reactions of mice brain to intracerebroventricular injection of thyroid peroxidase antibodies*

Авторы

  • Наталия Новикова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation 2 Institute of Experimental Medicine, 12, ul. Akademica Pavlova, St. Petersburg, 197376, Russian Federation
  • Кристина Деревцова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademica Pavlova, St. Petersburg, 197376, Russian Federation
  • Анастасия Дятлова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademica Pavlova, St. Petersburg, 197376, Russian Federation
  • Елена Корнева St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ; Institute of Experimental Medicine, 12, ul. Akademica Pavlova, St. Petersburg, 197376, Russian Federation
  • Тамара Федоткина Санкт-Петербургский государственный университет
  • Леонид Чурилов St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation ;St. Petersburg Research Institute of Phthisiopulmonology, Health Ministry of Russia, 2–4, Ligovskiy pr., St. Petersburg, 191036, Russian Federation
  • Евгения Ефимова St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation
  • Полина Соболевская St. Petersburg State University, 7–9, Universitetskaya nab., St. Petersburg, 199034, Russian Federation

DOI:

https://doi.org/10.21638/spbu11.2019.410

Аннотация

Hashimoto’s encephalopathy is a rare disease of a presumable autoimmune aetiology. It has been shown that patients with this disease have high levels of anti-thyroperoxidase autoantibodies both in blood and cerebrospinal fluid. Specific astrocyte binding of anti-thyroperoxidase autoantibodies suggests a role of these autoantibodies in the Hashimoto’s encephalopathy pathogenesis. In this study the binding of anti thyroperoxidase with various regions of mice brain after intracerebroventricular stereotaxic injection was assessed. The results revealed no specific immunopositive labels in various brain structures of the mice which were subjected to the intracerebroventricular stereotaxic anti-thyroperoxidase injection. Direct application of human polyclonal IgG with high anti-thyroperoxidase titer on brain sections of intact mice demonstrated the same results. Apparently, absence of immunopositive staining in brain structures in the experiment can be explained by single administration of polyclonal IgG which may not contain enough of antibodies with this specificity. Further investigation of anti-thyroperoxidase binding with brain tissue in conditions of repeated intracerebroventricular administration is required.

Ключевые слова:

Hashimoto’s encephalopathy, Hashimoto’s thyroiditis, intracerebroventricular stereotaxic injection, neuroimmune interactions

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References

Pinedo-Torres I., Paz-Ibarra J.L. Current knowledge on Hashimoto’s encephalopathy: a literature review. Medwave, 2018, vol. 18, no. 06, e7298.

Blanchin S., Coffin C., Viader F., Ruf J., Carayon P., Potier F., Reznik Y. Anti-thyroperoxidase antibodies from patients with Hashimoto’s encephalopathy bind to cerebellar astrocytes.Journal of neuroimmunology, 2007, no. 192 (1–2), pp. 13–20.

Katzav A., Ben-Ziv T., Chapman J., Blank M., Reichlin M., Shoenfeld Y. Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS-SLE (depression). Journal of autoimmunity, 2008,no. 31 (4), pp. 393–398.

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Опубликован

15.06.2020

Как цитировать

Новикова, Н. ., Деревцова, К., Дятлова, А., Корнева, Е., Федоткина, Т., Чурилов, Л., … Соболевская, П. (2020). Reactions of mice brain to intracerebroventricular injection of thyroid peroxidase antibodies*. Вестник Санкт-Петербургского университета. Медицина, 14(4), 299–301. https://doi.org/10.21638/spbu11.2019.410

Выпуск

Раздел

Неврология. Нейрохирургия. Психиатрия

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