Prevalence of vitamin D deficiency in elderly people with sarcopenia in the north-west of Russia

Авторы

  • Yuliya A. Safonova North-Western State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation
  • Evgeny G. Zotkin North-Western State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation
  • Galina M. Glazunova North-Western State Medical University named after I. I. Mechnikov, 41, ul. Kirochnaya, St. Petersburg, 191015, Russian Federation

DOI:

https://doi.org/10.21638/11701/spbu10.2019.107

Аннотация

Vitamin D deficiency is quite сommon and highly prevalent in some regions of the world,seriously сompromising quality of elderly people life. Optimal vitamin D level in serum is assoсiated with stronger muscles and indicates additional 4–11 % improvement of muscularperformance and 17 % risk reduction of elderly people fаlls. Inсreased risk of falls due to sarcopenia is strongly associated with such undеsirable health outcomes as disаbility, institutionalization, and eventually death. This study analyzes vitamin D status in 69 elderly people with sarcopenia among 230 patricipants (96.5 % of women, mean age of 74.1 ± 6.5 years), equaling to 30 % (8.7 % in men, 91.3 % in women) prevalence in this age group. For evaluation of sarcopenia level, EWGSOP criteria were used. Muscle strength was assessed by a handheld dynamometer and muscle functioning was evaluated by SPPB-tests (walking speed, Five-Times-Sit-to-Stand-Test and standing balance). Insufficient vitamin D supply was found in 97 % of subjects with sarcopenia and 85.8 % — without sarcopenia. Optimal vitamin D levels were identified only in 3 % of sarcopenic subjects and 14.2 % of non-sarcopenic ones with p < 0.01.Mean Vitamin 25 (OH) D level in general population constituted 19.6 ± 5.44 ng/ml. Mean vitamin D level amog sarcopenic subjects aged 65–84 years constituted 18.2 ± 3.04 ng / ml, while among older individuals aged 85+ years — 15.1 ± 6.43 ng / ml, p > 0.05. Histroy of falls within 12 months prior to the study was reported in 89.9 % of patients with sarcopenia. Among them vitamin D deficiency was found in 60.3 % (95 % CI: 53.0–67.4, χ2 = 8.81 with p = 0.012). 85.8 % of individuals with vitamin D deficiency had low muscle strength (χ2 = 174.61, p < 0.001). 60.4 % of participants with sarcopenia and vitamin D deficiency had low total SPPB score (CI: 45.3–74.2, p < 0.05). Obtained data is indicative of high vitamin D deficiency prevalence. It was found out that Sarcopenia increases risk of vitamin D deficiency by 1.2 times (RR 1.2,95 % CI: 1.06–1.36, p < 0.01) in all studied age groups.

Ключевые слова:

vitamin D prevalence, vitamin D level, elderly, sarcopenia

Скачивания

Данные скачивания пока недоступны.
 

Библиографические ссылки


References

Van Schoor N. M., Lips P. Worldwide vitamin D status. Best Practice & Research Clinical Endocrinology & Metabolism, 2011, vol. 25, no. 4, pp. 671–680. https://doi.org/10.1016/j.beem.2011.06.007

Lips P. Vitamin D status and nutrition in Europe and Asia. The Journal of Steroid Biochemistry and Molecular Biology, 2007, vol. 103, no. 3–5, pp. 620–625. https://doi.org/10.1016/j.jsbmb.2006.12.07

Bruyère O., Slomian J., Beaudart C., Buckinx F., Cavalier E., Gillain S., Petermans J., Reginster J. YPrevalence of vitamin D inadequacy in European women aged over 80 years. Archives of Gerontology and Geriatrics, 2014, vol. 59, no. 1, pp. 78–82. https://doi.org/10.1016/j.archger.2014.03.010

Holick M. F. Vitamin D deficiency. N. Engl. J. Med., 2007, vol. 357, no. 3, pp. 266–281. https://doi.org/10.1056/nejmra070553

Wacker M., Holick M. F. Vitamin D — Effects on skeletal and extraskeletal health and the need for supplementation. Nutrients, 2013, vol. 5, no. 1, pp. 111–148. https://doi.org/10.3390/nu5010111

Gendelman O., Itzhaki D., Makarov S., Bennun M., Amital H. A randomized double-blind placebocontrolled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Lupus, 2015, vol. 24, no. 4–5, pp. 483–489. https://doi.org/10.1177/0961203314558676

Heath K. M., Elovic E. P. Vitamin D deficiency—Implications in the rehabilitation setting. Am. J. Phys.Med. Rehab., 2006, vol. 85, no. 11, pp. 916–923. https://doi.org/10.1097/01.phm.0000242622.23195.61

Shinchuk L., Holick M. F. Vitamin D and rehabilitation: Improving functional outcomes. Nutr. Clin.Pract., 2007, vol. 22, no. 3, pp. 297–304. https://doi.org/10.1177/0115426507022003297

The DIPART Group. Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ, 2010, no. 340, p. b5463. https://doi.org/10.1136/bmj.b5463

Bolland M. J., Grey A., Gamble G. D., Reid I. R. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diab. Endocrinol., 2014, vol. 2, no. 4, pp. 307–320. https://doi.org/10.1016/s2213-8587(13)70212-2

Pourshahidi L. K. Vitamin D and obesity: current perspectives and future directions.Proceedings of the Nutrition Society,2014, vol. 74, no. 2, pp. 115–124. https://doi.org/10.1017/s0029665114001578

Antico A., Tampoia M., Tozzoli R., Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmunity Reviews, 2012, vol. 12, no. 2, pp. 127–136. https://doi.org/10.1016/j.autrev.2012.07.007

Seida J. C., Mitri J., Colmers I. N., Majumdar S. R., Davidson M. B., Edwards A. L., Hanley D. A., Pittas A. G., Tjosvold L., Johnson J. A. Effect of Vitamin D Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis. J. Clin. Endocrinol. Metab., 2014, vol. 99, no. 10, pp. 3551–3560. https://doi.org/10.1210/jc.2014-2136

Souberbielle J. C., Body J. J., Lappe J. M., Plebani M., Shoenfeld Y., Wang T. J., Bischoff-Ferrari H. A.,Cavalier E., Ebeling P. R., Fardellone P., Gandini S., Gruson D., Guérin A. P., Heickendorff L., Hollis B. W., Zittermann A. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmunity Reviews, 2010, vol. 9, no. 11, pp. 709–715. https://doi.org/10.1016/j.autrev.2010.06.009

Lavie C. J., Lee J. H., Milani R. V. Vitamin D and cardiovascular disease will it live up to its hype? J. Am. Coll. Cardiol., 2011, vol. 58, no. pp. 1547–1556. https://doi.org/10.1016/j.jacc.2011.07.008

Zheng Y., Zhu J., Zhou M., Cui L., Yao W., Liu Y. Meta-Analysis of Long-Term Vitamin D Supplementation on Overall Mortality. Meta-Analysis of Long-Term Vitamin D Supplementation on Overall Mortality. PLoS ONE, 2013, vol. 8, no. 12, p. e82109. https://doi.org/10.1371/journal.pone.0082109

Kalyani R. R., Stein B., Valiyil R., Manno R., Maynard J. W., Crews D. C. Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J. Am. Geriatr. Soc., 2010, vol. 58, no. 7, pp. 1299–1310. https://doi.org/10.1111/j.1532-5415.2010.02949.x

Bruyère O., Cavalier E., Souberbielle J. C., Bischoff-Ferrari H. A., Beaudart C., Buckinx F., Buckinx F.,Reginster J. Y., Rizzoli R. Effects of vitamin D in the elderly population: current status and perspectives. Archives of Public Health, 2014, vol. 72, no. 1, p. 32. https://doi.org/10.1186/2049-3258-72-32

Bischoff-Ferrari H. A. Relevance of vitamin D in muscle health. Rev. Endocr. Metab. Disord, 2012, vol. 13, no. 1, pp. 71–77. https://doi.org/10.1007/s11154-011-9200-6

Beaudart C., Buckinx F., Rabenda V., Gillain S., Cavalier E., Slomian J., Petermans J., Reginster J. Y.,Bruyère O. The Effects of Vitamin D on Skeletal Muscle Strength, Muscle Mass, and Muscle Power: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.J. Clin. Endocrinol. Metab., 2014, vol. 99, no. 11, pp. 4336–4345. https://doi.org/10.1210/jc.2014-1742

Bakhtiiarova S., Lesnyak O., Kuznetsova N., Blankenstein M. A., Lips P. Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia. Osteoporoz. Int., 2006, vol. 17, no. 3, pp. 441–446. https://doi.org/10.1007/s00198-005-0006-9 (In Russian)

Karonova T. L., Grineva E. N., Nikitina I. L., Tsvetkova E. V., Todieva A. M., Beliaeva O. D., Mikheeva E. P., Globa P. Yu., Andreeva A. T., Beletskaia I. S., Omelchuk N. V., Fulonova L. S., Shlyakhto E. V. Prevalence of vitamin D deficiency in the North-West region of the Russian Federation among residents of St.Petersburg and Petrozavodsk. Osteoporoz i osteopatii, 2013, vol. 16, no. 3, pp. 33–37. https://doi.org/10.14341/osteo201333-7 (In Russian)

Safonova Yu.A., Zotkin E. G., Glazunova G. M., Strukov E. L. Analysis of security by vitamin D of the elderly people. Adv. geront., 2018, vol. 31, no. 2, pp. 184–190. (In Russian)

Cruz-Jentoft A. J., Baeyens J. P., Bauer J. M., Boirie Y., Cederholm T., Landi, F., Martin F. C, Michel J.-P., Rolland Y., Schneider S. M., Topinkova E., Vandewoude M., Zamboni M. Sarcopenia:European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and Ageing, 2010, vol. 39, no. 4, pp. 412–423. https://doi.org/10.1093/ageing/afq034

Cruz-Jentoft A. J., Bahat G., Bauer J., Boirie Y., Bruyère O., Cederholm T., Cooper C., Landi, F.,Rolland Y., Sayer A. A., Schneider S. M., Sieber C. C., Topinkova E., Vandewoude M., Visser M.,Zamboni M. Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing, 2019, vol. 48, no. 1, pp. 16–31. https://doi.org/10.1093/ageing/afy169

Holick M. F., Binkley N. C., Bischoff-Ferrari H. A., Gordon C. M., Hanley D. A., Heaney R. P.,Heaney R. P., Hassan Murad M., Weaver C. M. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J. Clin. Endocrinol. Metab., 2011, vol. 96,no. 7, pp. 1911–1930. https://doi.org/10.1210/jc.2011-0385

Pludowski P., Karczmarewicz E., Bayer M., Carter G., Chlebna-Sokól D., Czech-Kowalska J.,Dębski R., Decsi T., Dobrzańska A., Franek E., Głuszko P., Grant W. B., Holick M. F., Yankovskaya, Konstantynowicz J., Książyk J. B., Księżopolska-Orłowska K., Lewiński A., Litwin M., Lohner S.,Lorenc R. S., Łukaszkiewicz J., Marcinowska-Suchowierska E., Milewicz A., Misiorowski W., Nowicki M., Povoroznyuk V., Rozentryt P., Rudenka E., Shoenfeld Y., Socha P., Solnica B., Szalecki M.,Tałałaj M., Varbiro S., Żmijewski M. A. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe — reccomendation of vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol. Pol, 2013, vol. 64, no. 4, pp. 319–327.https://doi.org/10.5603/ep.2013.0012

Fielding R. A., Vellas B., Evans W. J., Bhasin S., Morley J. E., Newman A. B., Gabor van Kan A., Andrieu S.,Bauer J., Breuille D., Cederholm T., Chandler J., C. De Meynard, Donini L., Harris T., Kannt A.,Guibert F. K., Onder G., Papanicolaou D, Rolland Y., Rooks D., Sieber C., Souhami E., Verlaan S.,Zamboni M. Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia. Journal of the American Medical Directors Association, 2011, vol. 12, no. 4, pp. 249–256. https://doi.org/10.1016/j.jamda.2011.01.003

Iannuzzi-Sucich M., Prestwood K. M., Kenny A. M. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J. Gerontol. A. Biol. Sci. Med. Sci., 2002, vol. 57, no. 12,pp. M772–777. https://doi.org/10.1093/gerona/57.12.m772

Cruz-Jentoft A. J., Landi F., Schneider S. M., Zuniga C., Arai H., Boirie Y., Chen L-K., Fielding R. A.,Martin F. C., Michel J.-P., Sieber C., Stout J. R., Studenski S. A., Vellas B., Woo J., Zamboni M.,Cederholm T. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review.Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age and Ageing, 2014, vol. 43,no. 6, pp. 748–759. https://doi.org/10.1093/ageing/afu115

Espinel-Bermúdez M. C., Ramírez-García E., García-Peña C., Salvà-Casanovas A., Ruiz-Arregui L., Cárdenas-Bahena A., Sánchez-García S. Prevalence of sarcopenia in community-dwelling older people of Mexico City using the EWGSOP (European Working Group on Sarcopenia in Older People)diagnostic criteria. J. Cachexia, Sarcopenia and Muscle, 2017, vol. 2, no. 2, pp. 12–17. https://doi.org/10.17987/jcsm-cr.v2i2.9

Boland R. Role of vitamin D in skeletal muscle function. Endocr. Rev., 1986, vol. 7, no. 4, pp. 434–448.https://doi.org/10.1210/edrv-7-4-434

Fougère B., Vellas B., van Kan G. A., Cesari M. Identification of biological markers for better characterization of older subjects with physical frailty and sarcopenia. Transl. Neurosci., 2015, vol. 6, no. 1,pp. 103–110. https://doi.org/10.1515/tnsci-2015-0009

Volpato S., Bianchi L., Cherubini A., Landi F., Maggio M., Savino E., Bandinelli S., Ceda G. P., Guralnik J. M., Zuliani G., Ferrucci L. Prevalence and clinical correlates of sarcopenia in communitydwelling older people: application of the EWGSOP definition and diagnostic algorithm. J. Gerontol. A.Biol. Sci. Med. Sci., 2014, vol. 69, no. 4, pp. 438–446. https://doi.org/10.1093/gerona/glt149

Gariballa S., Alessa A. Sarcopenia: prevalence and prognostic significance in hospitalized patients.Clin Nutr., 2013, vol. 32, no. 5, pp. 772–776. https://doi.org/10.1016/j.clnu.2013.01.010

Houston D. K., Cesari M., Ferrucci L., Cherubini A., Maggio D., Bartali B., Johnson M. A., Schwartz G. G., Kritchevsky S. B. Association between vitamin D status and physical performance: the InCHIANTI study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2007,vol. 62, no. 4, pp. 440–446.https://doi.org/10.1093/gerona/62.4.440

Mastaglia S. R., Seijo M., Muzio D., Somoza J., Nunez M., Oliveri B. Effect of vitamin D nutritional status on muscle function and strength in healthy women aged over sixty-five years. Journal of Nutrition,Health and Aging, 2011, vol. 15, no. 5, pp. 349–354. https://doi.org/10.1007/s12603-010-0287-3

Rosendahl-Riise H., Spielau U., Ranhoff A. H., Gudbrandsen O. A., Dierkes J. Vitamin D supplementation and its influence on muscle strength and mobility in community-dwelling older persons: a systematic review and metaanalysis. J. Hum. Nutr. Diet., 2017, vol. 30, no. 1, pp. 3–15. https://doi.org/10.1111/jhn.12394

Visser M. D., Deeg D. J. H., Lips P. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam.Journal of Clinical Endocrinology and Metabolism, 2003, vol. 88, no. 12, pp. 5766–5772. https://doi.org/10.1210/jc.2003-030604

Bischoff-Ferrari H. A., Dietrich T., Orav E. J., Hu F. B., Zhang Y., Karlson E. W., Dawson-Hughes B. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged>or=60 y. Am. J. Clin. Nutr., 2004, vol. 80, no. 3, pp. 752–758. https://doi.org/10.1093/ajcn/80.3.752

Загрузки

Опубликован

25.06.2019

Как цитировать

Safonova, Y. A., Zotkin, E. G., & Glazunova, G. M. (2019). Prevalence of vitamin D deficiency in elderly people with sarcopenia in the north-west of Russia. Вестник Санкт-Петербургского университета. Медицина, 14(1), 58–68. https://doi.org/10.21638/11701/spbu10.2019.107

Выпуск

Раздел

Внутренние болезни