Вестник Санкт-Петербургского университета. Медицина 2020-04-28T05:22:51+03:00 Яблонский Петр Казимирович Open Journal Systems <p>«Вестник Санкт-Петербургского университета. Медицина» — рецензируемый междисциплинарный научный журнал, публикующий работы российских ученых из различных медицинских организаций, университетов, научных институтов, а также результаты исследований авторов из зарубежных медицинских организаций и университетов стран ближнего и дальнего зарубежья, которые охватывают основные области фундаментальной и прикладной медицины.</p> The influence of selective serotonin reuptake inhibitors on behavior of adult Danio rerio in experimental depression 2020-04-28T05:22:48+03:00 Sergei Proshin Milana Dzhabrailova Yanina Kolesnik Magomed Saigidmagomedov Ali Dzeitov Polina Khаlturina Valentina Veizer <p>Depression is one the most common form of mental diseases. Due to epidemiological studies,it is common in different age groups including young people. Depression pathogenesis from the point of system perspective view consists of morphofunctional and pathopsychological components. The former can be divided into neuroanatomical, neurophysiological, neurochemical parts. Laboratory animals as experimental models are an invaluable tool for investigating pathogenesis of depressive disorders and creating potential treatments. In our study <em>Danio rerio </em>was used as an experimental model of depression. In fish schools during separation in pairs, anxious and aggressive behavior towards each other was manifested. It contributes to formation of dominant-subordinate relationships. Before administration of fluoxetine and sertraline in all the groups studied, the lower level of fish swimming was observed. They were hyperactive. Aggressive behavior towards each other was not observed. On the third day of the experiment behavior of the fish in groups with fluoxetine and sertraline was different. In group with sertraline 25 % of fishes come up to average level. In group with fluoxetine fishes remained at the bottom of the aquarium. On the fifth day of the experiment in the group with sertraline 25 % of fishes had an abnormal craniocaudal position of the body in space.</p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Proshin Sergei N., Dzhabrailova Milana M., Kolesnik Yanina О. , Saigidmagomedov Magomed A. , Dzeitov Ali Kh., Khаlturina Polina B., Veizer Valentina O. Psoriatic arthritis: current state of the problemPsoriatic arthritis: Current state of the problem 2020-04-28T05:22:49+03:00 Alexandr Shishkin Alina Nikolaeva Irina Smirnova <p>The article presents data on the prevalence, pathogenesis, clinical picture, diagnosis, treatment of psoriatic arthritis (PsA). Despite significant scientific advances, this pathology remains a serious medical and social problem. The etiology and pathogenesis of PsA are not fully understood. It leads to imperfect treatment methods. Given the polymorphism of clinical picture, as well as the lack of specific laboratory parameters, the diagnosis of PsA, especially at early stage, presents considerable difficulties. It is necessary to remember about the possibility ofdeveloping such socially significant comorbid conditions as hypertension, ischemic heart disease,type 2 diabetes, obesity, metabolic syndrome, inflammatory bowel disease, eye damage in patients with PsA. The pathology of the nails in patients with psoriasis and its relationship with the development and course of PsA is particularly interesting. The progressive nature of the damage to the musculoskeletal system, leading to a decreased function of the joints, disability, and impaired social adaptation, therefore the early diagnosis of PsA and the choice of optimal therapy are current priorities. A multidisciplinary approach to the management of PsA patients will facilitate the timely detection of pathology, as well as improve the quality of life of patients and the outcome of the disease.</p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Shishkin Alexandr N. , Nikolaeva Alina A. , Smirnova Irina O. Photo documentation in Dupuytren’s disease surgery 2020-04-28T05:22:49+03:00 Andrei Zhigalo Victor Morozov Vladimir Pochtenko Aleksei Ryapolov Vladislav Malyshev <p>Due to the rapid development of technology in the 21st century, the imaging and image processing became available to everyone. High-quality photos can be made by a regular smart phone. The high quality of current photos allows such images to be used in medicine for reporting documentation, remote consultation, as well as evaluation of treatment results. The main objective of this work is to describe rules and introduce standards of digital photography of Dupuytren’s disease surgery for obtaining high-quality photo documents. The materials for our study were represented by more than 60,000 digital photos for the period from 2003 to 2017. After studying, organizing, and processing of images, the optimal conditions, standard projections, and principles of photographing hands of Dupuytren’s disease patients were revealed to obtain the most reliable data. The stage of the disease, the number of palmar aponeurosis cords involved in the pathological process, the presence of changes on the skin (postoperative scars, skin retractions, nodes of the palmar aponeurosis), and finger flexion function can be assessed from photo documents. The data obtained from photos were checked against those obtained from patient examination. The described methods and standards will help in creating a high-quality personal photo and video archive, which is necessary for every practicing surgeon for systematization of observations, evaluation of long-term results, and demonstration of obtained results to colleagues as evidence. The authors are sure that in the nearest future we will become witnesses and participants of creation of a unified global database of clinical observations. The development of this resource will allow the efforts of surgeons from all over the world to be joined in the fight against a common enemy — Dupuytren’s disease.</p> <p>&nbsp;</p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Zhigalo Andrei V. , Morozov Victor V., Pochtenko Vladimir V., Ryapolov Aleksei V., Malyshev Vladislav I. Characteristics of the response to treatment in outpatients with the first episode of schizophrenia spectrum disorders 2020-04-28T05:22:49+03:00 Egor Chumakov Natalia Petrova Oleg Limankin <p><span style="background-color: #ffffff;">Identifying predictors of treatment response in patients with the first episode of schizophrenia spectrum disorders is an important issue in the field. The objective of the study was to assess the incidence of poor response to treatment and the factors that influence it in outpatients with the first episode of schizophrenia spectrum disorders. Medical records of the outpatients seeking treatment in 2017 in 3 day inpatient departments of the two districts in St. Petersburg, Russia, were examined. 73 patients diagnosed with schizophrenia spectrum disorders (ICD-10) met the criteria for the first episode (the duration of the disease is up to 5 years, the number of episodes is not more than three) and made up the study group. It has been established that up to 49 % of outpatients with the first episode of schizophrenia spectrum disorders were characterized by poor responses to antipsychotic therapy during outpatient treatment. Factors predicting a poor response to therapy may include earlier onset of illness, concomitant brain damage, and low adherence to therapy.</span></p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Chumakov Egor M. , Petrova Natalia N. , Limankin Oleg V. HPV and cervical lesion spread type specificity in women of reproductive age in Saint Petersburg 2020-04-28T05:22:50+03:00 Alexandr Gzgzyan Liailia Dzhemlikhanova Margarita Martirosyan Dariko Niauri Olga Sokolova Galina Safarian Elena Borodina <p><span style="background-color: #ffffff;">HIV infection is a risk factor for cervical cancer and both diseases show steady increase in Saint Petersburg. HIV-positive women are at greater risk of cervical dysplasia than HIV-negative women which may be as a result of immunosupression, hence adding more burdens to their already worsening health condition. The impact of highly active antiretroviral therapy (HAART) on HPV infection and cervical diseases associated with HPV remains uncertain. Type-specific prevalence of HR-HPV, risk factors for cervical precancer and cancer among Russian HIV-positive women were not previously estimated. The present study objective is determined by lack of HPV infection feature data as well as that of HPV-associated cervical disease, depending on HIV infection severity and HAART employment in HIV-infected St. Petersburg female population.</span></p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Gzgzyan Alexandr M. , Dzhemlikhanova Liailia Kh. , Martirosyan Margarita M., Niauri Dariko A., Sokolova Olga I., Safarian Galina Kh., Borodina Elena S. MR anatomy, anatomical variants and morphometry of hippocampal formation 2020-04-28T05:22:50+03:00 Natalia Ananyeva Evgeniy Andreev Linara Akhmerova Tatiana Salomatina Ludvig Wasserman Ruslana Grebenshchikova Nikolay Neznanov Alexey Pichikov Natalya Zalutskaya <p><span style="background-color: #ffffff;">Nowadays the question of limbic structures involvement in different types of brain pathology is much debated in literature. However, obtained results are often contradictory. This can be explained by the insufficient knowledge of normal volume and linear measurements of brain structures responsible for human emotional and cognitive functioning including different age periods. Different anatomical variants of these structures were described in literature indistinctly, often leading to misinterpretation of neuroimaging findings. Besides, hippocampal formation, being complex structure, consists of different parts, including subregions (head, body and tail) and subfields (СА1-СА4, subiculum, presubiculum, dentate gyrus), which changes depend on different psychological and psychiatric symptoms. In our study we have analyzed MRI data of mediobasal parts of temporal lobes in healthy volunteers based on literature review and our own experience. The incidence rate of different hippocampal anatomical variants in healthy population was specified in the study. We have also determined MR voxel-based morphometry as a method permitting to define and evaluate volumes of different hippocampal subfields. In our research we found out certain significant differences in hippocampus fissure volumes, parasubiculum, molecular layer of dentate gyrus, fimbria, СА3 and СА4 Brodmann areas, demonstrating that in adulthood morphofunctional connections are not finally formed, that’s why volumes of molecular layers CA1-CA3 smaller in adulthood than in elder population. But hippocampal fissure become smaller in elder ages because of atrophic changes.</span></p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Ananyeva Natalia I., Andreev Evgeniy V., Akhmerova Linara R. , Salomatina Tatiana A. , Wasserman Ludvig I., Grebenshchikova Ruslana V. , Neznanov Nikolay G. , Pichikov Alexey A., Zalutskaya Natalya M. Healthcare innovation — experiences from the Netherlands 2020-04-28T05:22:50+03:00 Fredrik Boer <p><span style="background-color: #ffffff;">Healthcare delivery is challenged because of the increasing burden of costs as a result of technological developments and in many countries also as a result of aging. In order to keep healthcare accessible we must innovate not only in the medical possibilities but also in the way we deliver healthcare. Opportunities lie in technological innovation, digitalisation, patient centred care, business development and the paradigms we use in healthcare. Digitalization plays an important role, as this enables use to use information throughout the care process. Digitalisation starts with the use of electronic health records.Furthermore, eHealth makes it possible to involve the patient in his own care by shared decision making, self management and home monitoring. Digitalisation can also improve care through decision support systems, developing predictive tools through machine learning and artificial intelligence. Good care requires that information can be shared between healthcare providers and thus data must be exchangeable between systems — interoperability. Next to digitalisation other improvements play an important role such as value based medicine, that puts the value of care for the patient first, development of new organisation of healthcare and new (cheaper) business models.</span></p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Boer Fredrik Diet food in the public catering system — an important direction in the health care of Russia population 2020-04-28T05:22:51+03:00 Viktor Zakrevskii Stanislav Lopatin <p><span style="background-color: #ffffff;">The article presents data on the state of public catering in Russia, peculiarities of eating behavior of various categories of the population in modern conditions. It is noted that most adults consume a significant amount of animal fats, trans isomers of fatty acids, salt, simple carbohydrates and an insufficient amount of vegetables and fruit, fish and seafood. It also states he absence of a link between the nutritional behavior of the population, depending on their mood and psychological status, and the technological and assortment policies of food industry enterprises, focused on the use of modern advances in scientific and technological progress. The article highlights key indicators of the catering market of Russia, the USA and Canada, such as the average per capita cost of food “outside the house”, the share of food “outside the house” in the structure of food costs and catering market volume. A positive result of a systematic approach to the organization of diet in the USSR is shown. The conclusion about the feasibility of a phased restoration of dietary elements outside the home for all categories of consumers.</span></p> 2020-04-23T00:00:00+03:00 Copyright (c) 2020 Zakrevskii Viktor V. , Lopatin Stanislav A.